Utsi Wa Njoka Wochokera ku Agkistrodon (Njoka ya masitepe asanu) Uyenera Kuthandizidwa Ndi Chithunzi Chowonetsedwa ndi Seramu ya Antihematic

Ululu wa Njoka Wochokera ku Agkistrodon (Njoka ya masitepe asanu) Uyenera Kuthandizidwa Ndi Seramu Yothira Magazi

Kufotokozera Kwachidule:

Mayesero awiri a zachipatala anachitidwa, mayesero oyendetsedwa ndi placebo komanso mayesero oyendetsedwa bwino.Mabala onse anali akutuluka magazi chifukwa chodulidwa khoma la m'mimba pochita opaleshoni ya m'mimba.Zizindikiro zazikulu zochizira zinali kutaya magazi, nthawi ya hemostasis ndi kutaya kwa magazi pagawo lililonse.Mwachisawawa placebo m'mayesero azachipatala mu milandu 180 ya anthu: kuchuluka kwa mfundo zongofanana ndi placebo, 2 u ndi 3 u magulu atatu, preoperative mphindi 15-20 limodzi mtsempha wamagazi mlingo, zotsatira zikusonyeza izi Mlingo awiri mu magazi, nthawi magazi ndi. kutayika kwa magazi pa chiwerengero cha chigawo cha unit kunali kopambana kuposa placebo, koma palibe mgwirizano wokhazikika pakati pa magulu awiri.Mu mayesero abwino kulamulira, panali 324 odwala mu experimental gulu ndi 108 odwala mu ulamuliro gulu, ndi mlingo umodzi wa 2U anapatsidwa mu experimental gulu 15-20 mphindi pamaso opaleshoni ndi limodzi mtsempha wa magazi jekeseni.Palibe zoyipa zomwe zidawonedwa m'mayeso omwe ali pamwambawa.

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kafukufuku wasonyeza kuti njoka zaululuzi makamaka zimatulutsa poizoni wozungulira magazi ndi ma neurotoxins, omwe angayambitse kufalikira kwa intravascular coagulation (DIC) ndikutuluka magazi, kugwedezeka komanso kulephera kwa ziwalo zingapo.Kutengera kafukufuku wokhazikika wa magazi toxicology ya njoka ya njoka kum'mwera kwa Anhui, DIC inapezeka kuti ndi imodzi mwamakhalidwe achilengedwe a odwala ovulala ndi njoka omwe anali ndi poizoni woyambirira, zomwe zinali zosiyana ndi zomwe DIC imanena.Choncho, lingaliro la "DIC ngati" matenda odwala njoka kulumidwa anafunsidwa kwa nthawi yoyamba mu China (1988).Zinapezeka kuti TLE ndi FE ndizo zomwe zimayambitsa "DIC ngati" (1992).Izi ndizofunika kwambiri kuti tifotokoze makhalidwe a kusintha kwa magazi kwa odwala omwe ali ndi ululu wa njoka ya masitepe asanu, komanso amapereka maziko ongoganizira za kugwiritsa ntchito antivenin yeniyeni kuti athetse vutoli.

Pakafukufuku wamakina otulutsa magazi omwe amachititsidwa ndi minyewa isanu ya njoka, apezanso kuti utsi wa njokawu umakhudza magawo atatu a thupi la hemostatic system (coagulation factor, mapulateleti ndi khoma la mtsempha wa magazi), pomwe magazi amatuluka. poizoni mwachindunji zimakhudza permeability wa capillaries.Panthawi imodzimodziyo, zinapezeka kuti kutuluka kwa magazi kwakukulu ndi kutupa kwa miyendo yovulalayo sikunali kosavuta kuthetsa, zomwe zinali zokhudzana ndi kutsekeka kwa magazi a thoracic duct lymphatic coagulation factor komanso kuchepa kwa kuthamanga kwa magazi.Pogwirizana kwa nthawi yayitali ndi qimen Snakebite Institute, zotsatira zoyamba ndi zogwiritsidwa ntchito zofufuza zakhala zikuthandiza kwambiri pokonzekera bwino ndondomeko ya chithandizo cha kulumidwa ndi njoka ndikuwonetsetsa chitetezo cha odwala omwe ali ndi njoka, ndipo apindula kwambiri ndi anthu.Zochita zafukufuku zapambana mphoto ya Science and Technology Achievement Award ya Anhui Province, Science and Technology Progress Award ya Anhui Province (1993), Ministry of Health (A) Grade Science and Technology Achievement Group Award (1991);Mu 1989, kampaniyo inagwirizana ndi Wuhan Institute of Biological Products kuti apange anti-monoclonal anti-penta snake venom thrombin, yomwe inali kupambana koyamba ku China.Mu 1996, kampaniyo inapanga pamodzi ndikupanga mankhwala a thrombin ndi Institute of Biological Products and Drugs of Jinan Military Command (Yuwei Drug Approval No. 118004, Patent CN1141951A).