Institute of Snake Venom and Snakebite, Southern Anhui Medical College

Institute of Snake Venom and Snakebite, Southern Anhui Medical College

Research Institute of Wuhu City, Anhui Province

Kafukufuku wokhudza utsi wa njoka ndi bala la njoka ku Southern Anhui Medical College adayamba pakati pa zaka za m'ma 1970, ndipo anali membala wa Anhui Provincial Snake Wound Treatment Cooperation Group panthawiyo.Ndi limodzi mwamabungwe oyambilira kuchita kafukufuku woyambira komanso wogwiritsa ntchito pauyo wa njoka ku China.

Dzina lachi China

Institute of Snake Venom and Snakebite, Southern Anhui Medical College

malo

Chigawo cha Anhui

mtundu

sukulu yaukachenjede wowonjezera

chinthu

Chilonda cha Njoka ndi Chilonda cha Njoka

Zotsatira za kafukufuku wa Institute

Chiyambi cha Institute

Kafukufuku wokhudza utsi wa njoka ndi bala la njoka ku Southern Anhui Medical College adayamba pakati pa zaka za m'ma 1970, ndipo anali membala wa Anhui Provincial Snake Wound Treatment Cooperation Group panthawiyo.Mu 1984, motsogozedwa ndi Pulofesa Wen Shangwu, mkulu wa dipatimenti yophunzitsa ndi kufufuza kwa ophunzira oyambirira omwe anali odwala, ofesi ya Njoka ya Poizoni ndi Njoka ya Njoka inakhazikitsidwa, yomwe ndi imodzi mwa mabungwe oyambirira kuchita kafukufuku wofunikira komanso wogwiritsidwa ntchito. pa ululu wa njoka ku China.Mu 2007, Snake Poison and Snakebite Research Office idatchedwanso Snake Poison Research Institute of Southern Anhui Medical College, ndipo wotsogolera pano ndi Pulofesa Zhang Genbao.M'zaka zapitazi za 30, zoyamba ndi zogwiritsidwa ntchito kafukufuku zomwe zapindula za poizoni wa njoka zam'mphepete mwa nyanja kum'mwera kwa Anhui zathandiza kwambiri kupewa ndi kuwongolera kuvulala kwa njoka ndi kugwiritsa ntchito zida zaukali wa njoka ku China;Njoka zazikulu zaululu kum'mwera kwa Anhui ndi Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head ndi Bungarus multicinctus, makamaka Agkistrodon acutus, yomwe imakhudza kwambiri thanzi ndi moyo wa anthu akumapiri.Kafukufuku wasonyeza kuti njoka zaululuzi makamaka kutulutsa magazi poizoni ndi neurotoxins, amene angachititse odwala kudwala disseminated intravascular coagulation (DIC) ndi yachiwiri magazi, mantha, angapo ziwalo kulephera ndi zotsatira zina zazikulu;Kupyolera mu kafukufuku wokhazikika wamagazi a poizoni wa poizoni wa Agkistrodon acutus (Agkistrodon acutus) kum'mwera kwa Anhui, anapeza kuti DIC yokhudzana ndi kulumidwa ndi njoka inali imodzi mwa zizindikiro zakupha koyambirira, ndipo inali yosiyana ndi DIC yomwe imafotokozedwa mwachikhalidwe. malingaliro.Chifukwa chake, lingaliro la "DIC ngati" syndrome mwa odwala omwe adalumidwa ndi Agkistrodon acutus idaperekedwa koyamba ku China (1988), idadziwikanso kuti thrombin ngati enzyme (TLE) ndi fibrinolytic enzyme (FE) yomwe ili muuvu wa Agkistrodon acutus anali. zifukwa zazikulu za "DIC ngati" (1992).Izi ndi zofunika kwambiri kumveketsa makhalidwe a magazi kusintha odwala Agkistrodon acutus, komanso amapereka maziko ongoyerekeza ntchito yeniyeni antivenin kuchiza Vutoli.Pakafukufuku wokhudza momwe magazi amagwirira ntchito chifukwa cha utsi wa Agkistrodon acutus, zidapezekanso kuti utsi wa njokawu udakhudza magawo atatu a hemostatic system (coagulation factor, mapulateleti ndi makoma amitsempha yamagazi), pomwe haemotoxin mwachindunji. amakhudza permeability wa capillaries.Panthawi imodzimodziyo, zinadziwika kuti magazi aakulu omwe amayamba chifukwa cha poizoni wa Agkistrodon acutus komanso kuvutika kwa kutupa kwa ziwalo zovulala kuti ziwonongeke zinali zokhudzana ndi kutsekeka kwa ma lymphatic supplement of coagulation factor mu thoracic duct komanso kuchepa kwa magazi.Zofunikira zazikuluzikulu zomwe zakwaniritsidwa komanso zogwiritsidwa ntchito pa kafukufukuyu zathandizira kwambiri mgwirizano wanthawi yayitali ndi Qimen Snakebite Research Institute popanga bwino njira yochizira kulumidwa ndi njoka yapoizoni ndikuwonetsetsa kuti odwala omwe alumidwa ndi njoka ali otetezeka, ndipo apindula kwambiri ndi anthu.Zochita zafukufukuzo zapambana mphoto ya Science and Technology Achievement Award of Anhui Province, Science and Technology Progress Award of Anhui Province (1993), ndi (A) level Science and Technology Achievement Collective Award ya Ministry of Health (1991);Mu 1989, idagwirizana ndi Wuhan Institute of Biological Products kupanga antibody monoclonal motsutsana ndi thrombin ngati enzyme ya Agkistrodon acutus venom, yomwe inali kupambana koyamba ku China;Mu 1996, izo pamodzi kupanga ndi kupanga mankhwala thrombin (YWYZZ 1996 No. 118004, patent CN1141951A) ndi Institute of Biological Zamgululi ndi Mankhwala a Jinan Military Region.

zofukufuku

M'zaka zaposachedwa, labotale yalekanitsa ndi kuyeretsa zinthu zosiyanasiyana za bioactive kuchokera ku utsi wa Agkistrodon acutus, Agkistrodon halys ndi Cobra kum'mwera kwa Anhui, monga anti hypercoagulable state enzymes, protein C activators (PCA).Kafukufuku woyeserera watsimikizira kuti zosakaniza zogwira izi zimatha kukhudza kugawanika kwa magazi, kukhudza kuphatikizika kwa mapulateleti, kuphatikizika ndikuteteza magwiridwe antchito a mitsempha ya endothelial, komanso kukhala ndi magwiridwe antchito apamwamba komanso otsika kawopsedwe a anticoagulation ndi zotsatira za thrombolytic, Izi ndizofunikira kwambiri popewa komanso kuchiza. thrombotic matenda ndi kusintha kwa magazi hypercoagulability;Panthawi imodzimodziyo, zinapezekanso kuti PCA kuchokera ku njoka ya njoka imakhala ndi zotsatira zenizeni zakupha maselo a khansa ya m'magazi a K562 ndikuletsa metastasis ya maselo a khansa.Chiyembekezo chake chachipatala ndi chachikulu kwambiri.Ofesi yofufuzayo yachita ndikumaliza ntchito zambiri zofufuza, monga "Mechanism of DIC yoyambitsidwa ndi Agkistrodon acutus venom", "Kafukufuku wa momwe magazi amachitidwira ndi utsi wa Agkistrodon acutus pazinyama", "Kuzindikira kulumidwa ndi njoka komanso kuzindikira kwake kosiyana. banja la njoka ndi njira yolembera ma enzyme", mothandizidwa ndi National Natural Science Foundation, Unduna wa Zaumoyo, Dipatimenti ya Zaumoyo ndi Dipatimenti Yophunzitsa za Chigawo cha Anhui;Pakalipano, ntchito zomwe zikukula zikuphatikizapo: "Kafukufuku wa Protein ya Hemorrhagic Anticoagulant ya Agkistrodon acutus", "Kafukufuku wa Molecular Mechanism of Effect of PCA kuchokera ku Agkistrodon halys Pallas Venom pa Vascular Endothelial Function", "Research Biology ya Molecular PCA yochokera ku Agkistrodon acutus Venom motsutsana ndi Ma cell Tumor”, ndi Kupatukana ndi Kuyeretsedwa kwa Nerve Analgesic Components kuchokera ku Cobra Venom.

Bungwe lofufuza za njoka za njoka ku South Anhui Medical College lili ndi mikhalidwe yabwino, zida zonse zofufuzira, kapangidwe ka gulu lochita kafukufuku, komanso kupita patsogolo kosalekeza kwa njira zofufuzira ndi njira zaukadaulo.Zikuyembekezeka kupanga zatsopano mu kafukufuku wa sayansi, maphunziro a anthu ogwira ntchito, ndi zina zotero. Zida za njoka za njoka kum'mwera kwa Anhui ndizolemera kwambiri komanso zamtengo wapatali.Pharmacy ya njoka za njoka ndi mankhwala omwe ali ndi ufulu wazinthu zanzeru ku China.Zotsatira za kafukufuku pamaziko ndi kugwiritsa ntchito kwa njoka ya njoka ndi zigawo zake ndizofunika kwambiri pa chitukuko cha chuma cha njoka ya njoka kum'mwera kwa Anhui ndi ntchito zachipatala.