Kuletsa kwa antitumor chigawo choyamba cha Agkistrodon halys venom pakukula kwa khansa ya m'mapapo ya anthu ma cell A549.

[Mwachidule] Cholinga: Kuphunzira zotsatira za Agkistrodon acutus venom tumor suppressor component I (AAVC-I) pa kuletsa kuchulukitsitsa ndi apoptosis ya khansa ya m'mapapo ya anthu A549 maselo.Njira: Miyezo yoletsa ya AAVC-I pamagulu osiyanasiyana pa maselo a A549 a 24h ndi 48h anayesedwa ndi njira ya MTT;HE staining ndi Hoechst 33258 fluorescence staining anagwiritsidwa ntchito kuona apoptosis kuchokera morphology;Mawonekedwe a bax protein adadziwika ndi immunohistochemistry.Zotsatira: MTT inasonyeza kuti AAVC-I ikhoza kulepheretsa kufalikira kwa maselo a A549 mu nthawi yodalirika komanso yodalira mlingo;Pambuyo pa chithandizo cha AAVCI kwa maola 24, nyukiliya pyknosis, matupi a nyukiliya a hyperchromatic ndi apoptotic adawonedwa pansi pa microscope;Immunohistochemistry inawonetsa kuti kuchuluka kwa kuwala kwapakati kumawonjezeka ndi kuchuluka kwa mankhwala osokoneza bongo, kusonyeza kuti mafotokozedwe a mapuloteni a bax anali ofanana.Kutsiliza: Antitumor chigawo choyamba cha Agkistrodon acutus venom amatha kuletsa khansa ya m'mapapo ya anthu A549 maselo ndikupangitsa apoptosis, yomwe ingakhale yokhudzana ndi kuwongolera kwa mawu a bax.