Kodi kuchitira retinal mtsempha kutsekeka?

[Mwatsatanetsatane] Cholinga Chopatula ndi kuyeretsa mapuloteni oletsa magazi kutuluka ku Agkistrodon acutus venom kum'mwera kwa Anhui ndikuwona zomwe zimalepheretsa ma cell amtima amtundu wa endothelial.Njira Ma cell amtundu wa endothelial cell EC-304 adakulitsidwa mu m'galasi.CCK-8 colorimetry idagwiritsidwa ntchito kudziwa cytotoxicity ya kachigawo kakang'ono ka anticoagulant protein ka Agkistrodon halys venom pa ma cell a EC-304 opangidwa mu vitro.Kusiyanitsa kwa microscopy kunagwiritsidwa ntchito kuwona kusintha kwa ma cell morphology ndi biochemistry ya maselo a EC-304 omwe amathandizidwa ndi kachigawo kakang'ono ka anticoagulant protein ka Agkistrodon halys venom.Zotsatira Gawo la mapuloteni a anticoagulant a Agkistrodon halys venom anali ndi cholepheretsa kukula kwa maselo a EC-304 (P μ The anticoagulant protein part of Agkistrodon halys venom (g/mL) inali ndi mphamvu yoletsa kwambiri ma cell a EC-304, ndipo kuchuluka kwa zoletsa kumawonjezeka. Maselo a EC-304 omwe amathandizidwa ndi anticoagulant protein kuchokera ku Agkistrodon halys venom adawonetsa kusintha kwa ma morphological Pansi pa maikulosikopu, ma cell anali ozungulira, kuchuluka kwa maselo oimitsidwa kumawonjezeka, kuchuluka kwa magawo agawidwe a cell kumachepa, Kutsiliza The anticoagulant protein kachigawo cha Agkistrodon acutus venom kuchokera kum'mwera kwa Anhui Province ali amphamvu chopinga amakhudza EC-304 maselo, ndi inducing apoptosis wa EC-304 maselo kungakhale imodzi mwa njira zake.