Kugwiritsa Ntchito Seven Antithrombotic Agents
Pali mitundu iwiri ya mapuloteni omwe ali ndi antithrombotic mu ululu wa njoka, wina amatha enzyme yokhudzana ndi puloteni ya fibrinolytic imatchedwa fibrinolytic enzyme (plasmine, FLE). hydrolysis ya zinthu zina coagulation Ndipo kupatsidwa zinthu za m`mwazi nembanemba, ndi zoonekeratu antithrombotic kwenikweni.Zina ndi kupondereza Prothrombin kukonzekera ndi adamulowetsa kuti achedwetse coagulation ndondomeko, ndipo alibe enzyme ntchito.
Mtundu uwu wa enzyme unapangidwa koyamba ndi Atoda et al Ndipo kambiranani za anticoagulation puloteni ya anticoagulant, Zimatsimikiziridwa kuti zotsatira za coagulation factor IX kapena coagulation factor X pa calcium ion Kupanga 1: 1 zovuta kuti ziwonjezeke nthawi ya coagulation;Pambuyo pake, Lu et al.kuchokera ku Agkistrodon acutus kumwera kwa Anhui A anticoagulant factor ACFI anali atalekanitsidwa ndi utsi wa njoka.Liu Qing Liang et al.anapeza kuti ACFI ili ndi calcium ion, Zinatsimikiziridwanso kuti ntchito yake ya anticoagulant ndi mapangidwe a malo anali okhudzana ndi ayoni a calcium. Pambuyo pake, Xu Xiaolong ndi ena analekanitsa utsi wa Agkistrodon acutus ndi Agkistrodon acutus ndi njira yolekanitsa bwino. Kafukufuku wogwiritsa ntchito makina adapeza kuti ikufanana ndi AC FI ndipo ili m'gulu lachiwiri.Zhai Ning et al.anapatula ne anticoagulant factor kuchokera ku poizoni wa Agkistrodon acutus, ndipo Zake zakuthupi ndi zamankhwala zidaphunziridwa, ndipo zidapezeka kuti zinalibe ntchito ya fibrinolytic komanso ntchito ya phospholipase A 2 komanso ntchito yamagazi.Qian Xiaojiang ndi ena analekanitsa utsi wa Agkistrodon acutus ndi Hunan The fibrinolytic yogwira chigawo chimodzi ndi kutsimikiziridwa ndi thrombolytic mayeso mu m'galasi Zimakhala zoonekeratu thrombolytic zotsatira.Lei Danqing adasiyanitsidwa ndi njira zitatu za chromatography Ndipo ntchito ya plasmin imakula kwambiri.Chifukwa chigawo cha plasmin chili ndi gawo la magazi ndizovuta kupatukana, ndipo kufunika kwake kwachipatala sikudziwika.Li Zhaoyan et al Kupyolera mu kuyesetsa kupeza fibrinolytic enzyme popanda zigawo za magazi Thandizo laukadaulo limaperekedwa ndi.Zhou Xianli [18] anatsimikizira kupyolera mu zoyesera kuti Thrombin monga enzyme ndi plasmin kuchokera ku Agkistrodon halys venom ali ndi zotsatira zoonekeratu za thrombolytic, koma Zotsatira zachindunji za plasmin ndi zamphamvu kuposa za thrombin ngati enzyme, Choncho, thrombin ngati enzyme ndi pang'onopang'ono thrombolytic wothandizira, zimapangitsa kukonzanso kwa mitsempha yamagazi pang'onopang'ono, Kupititsa patsogolo kulolerana kwa mitsempha yamagazi m'dera la ischemic, ndikupulumuka kuphulika kwa mitsempha chifukwa cha kutsekemera kwa magazi Cleavage imakhala ndi zotsatira zabwino pa gawo loyambirira la thrombosis, ndipo zonsezi zimagwiritsidwa ntchito pamodzi, zimatha kuchepetsa Mlingo ndi kukwaniritsa anticoagulant ndi thrombolytic zotsatira. Kugwiritsa Ntchito Zisanu ndi ziwiri Antithrombotic Agents Pali mitundu iwiri ya mapuloteni okhala ndi antithrombotic kwenikweni mu njoka ya njoka, wina amatha The puloteni okhudzana ndi fibrinolytic enzyme amatchedwa fibrinolytic enzyme (plasmine, FLE). Fibrinogen wonyozeka, Palibe kutsegula kwa plasminogen m'thupi la munthu, palibe hydrolysis ya zinthu zina coagulation Ndi kupatsidwa zinthu za m'mwazi nembanemba, zoonekeratu antithrombotic kwenikweni.Zina ndi kupondereza Prothrombin kukonzekera ndi adamulowetsa kuti achedwetse coagulation ndondomeko, ndipo alibe enzyme ntchito.
Mtundu uwu wa enzyme unapangidwa koyamba ndi Atoda et al Ndipo kambiranani za anticoagulation puloteni ya anticoagulant, Zimatsimikiziridwa kuti zotsatira za coagulation factor IX kapena coagulation factor X pa calcium ion Kupanga 1: 1 zovuta kuti ziwonjezeke nthawi ya coagulation;Pambuyo pake, Lu et al.kuchokera ku Agkistrodon acutus kumwera kwa Anhui A anticoagulant factor ACFI anali atalekanitsidwa ndi utsi wa njoka.Liu Qing Liang et al.anapeza kuti ACF ili ndi calcium ion Zinatsimikiziridwanso kuti ntchito yake ya anticoagulant ndi kapangidwe ka malo zinali zokhudzana ndi ayoni a calcium.Pambuyo pake, Xu Xiaolong ndi ena analekanitsa utsi wa Agkistrodon acutus kuchokera ku Agkistrodon acutus ndi njira yabwino yolekanitsa Chinthu china cha anticoagulant ACFI I Kafukufuku wogwiritsira ntchito makina anapeza kuti ndi ofanana ndi AC FI ndipo ali m'gulu lachiwiri.Zhai Ning et al.analekanitsa chinthu chatsopano cha anticoagulant kuchokera ku poizoni wa Agkistrodon acutus, ndipo Zake zakuthupi ndi mankhwala zinaphunziridwa, ndipo zinapezeka kuti zinalibe ntchito ya fibrinolytic komanso palibe phospholipase A 2 ntchito ndi ntchito ya magazi.Qian Xiaojiang ndi ena analekanitsa utsi wa Agkistrodon acutus ndi Hunan The fibrinolytic yogwira chigawo chimodzi ndi kutsimikiziridwa ndi thrombolytic mayeso mu m'galasi Zimakhala zoonekeratu thrombolytic zotsatira.Lei Danqing adasiyanitsidwa ndi njira zitatu za chromatography Ndipo ntchito ya plasmin imakula kwambiri.Chifukwa chigawo cha plasmin chili ndi gawo la magazi ndizovuta kupatukana, ndipo kufunika kwake kwachipatala sikudziwika.Li Zhaoyan et al Kupyolera mu kuyesetsa kupeza fibrinolytic enzyme popanda zigawo za magazi Thandizo laukadaulo limaperekedwa ndi.Zhou Xianli [18] anatsimikizira kupyolera mu zoyesera kuti Thrombin monga enzyme ndi plasmin kuchokera ku Agkistrodon halys venom ali ndi zotsatira zoonekeratu za thrombolytic, koma Zotsatira zachindunji za plasmin ndi zamphamvu kuposa za thrombin ngati enzyme, Choncho, thrombin ngati enzyme ndi pang'onopang'ono thrombolytic wothandizira, zimapangitsa kukonzanso kwa mitsempha yamagazi pang'onopang'ono, Kupititsa patsogolo kulolerana kwa mitsempha yamagazi m'dera la ischemic, ndikupulumuka kuphulika kwa mitsempha chifukwa cha kutsekemera kwa magazi Cleavage imakhala ndi zotsatira zabwino pa chiyambi cha thrombosis, ndipo zonsezi zimagwiritsidwa ntchito pamodzi.
Itha kuchepetsa mlingo ndikukwaniritsa anticoagulant ndi thrombolytic zotsatira.
Nthawi yotumiza: Oct-19-2022